ChloroquineV1, Main, Exploration, bibRecord, 002734

Polylysine-based transfection systems utilizing receptor-mediated delivery

Identifieur interne : 002734 ( Main/Exploration ); précédent : 002733; suivant : 002735

Polylysine-based transfection systems utilizing receptor-mediated delivery

Auteurs : Wolfgang Zauner [Autriche] ; Manfred Ogris [Autriche] ; Ernst Wagner [Autriche]

Source :

Advanced Drug Delivery Reviews [ 0169-409X ] ; 1998.

RBID : ISTEX:B47D4863145440EB80A5D75A2A82AF74417DE37C

English descriptors

Teeft :
- Acad, Acta, Adenovirus, Adenovirus receptor, Airway, Airway epithelium, Amino groups, Biochemistry, Biochim, Bioconjugate, Bioconjugate chem, Biol, Biophys, Birnstiel, Cationic liposomes, Cell lines, Cell type, Cell types, Cellular uptake, Charge ratio, Chem, Chloroquine, Circular dichroism, Complement system, Curiel, Drug deliv, Drug delivery reviews, Electron microscopy, Endocytosis, Endosomal, Endosomolytic, Epithelial, Eukaryotic cells, Ferkol, Gene, Gene delivery, Gene expression, Gene therapy, Gene transfer, Gene transfer systems, Genetic material, Glycerol, Hepatocytes, Hepg2, Huang, Internal vesicles, Intravenous application, Ligand, Lipid, Macrophage, Mammalian cells, Methods enzymol, Molecular weight, Mouse lung, Nacl, Natl, Negative charges, Nucleic acids, Peptide, Perales, Plasmid, Ply, Polycations, Polylysine, Polymeric immunoglobulin receptor, Primary hepatocytes, Proc, Receptor, Receptormediated gene transfer, Size distribution, Soluble complexes, Successful gene transfer, Tfplys, Transfected, Transfection, Transfection levels, Transferrin, Vesicle, Vivo, Vivo gene transfer, Zatloukal, Zauner.

Abstract

Abstract: Receptor-mediated gene transfer is a promising gene delivery technique. It employs a DNA-binding polycation, such as polylysine, to compact plasmid DNA to a size that can be taken up by cells (<100–200 nm). To allow internalization by receptor-mediated endocytosis, cell binding ligands, such as asialoglycoproteins or galactose for hepatocytes, anti-CD3 and anti-CD5 for T-cells, and transferrin, have been covalently attached to polylysine. Intracellular barriers for successful gene transfer include release of DNA complexes from endosomes or lysosomes, nuclear import of DNA complexes, and disassembly of the DNA–polylysine particles. Release of particles from internal vesicles has been achieved by the addition of lysosomotropic agents or glycerol to the transfection medium, or by the incorporation of endosomolytic compounds, such as viruses or membrane active peptides. This technique has already been used to transfect certain organs in vivo, including liver and lung.

Url:

https://api.istex.fr/ark:/67375/6H6-98RR19S0-N/fulltext.pdf

DOI: 10.1016/S0169-409X(97)00110-5

Affiliations:

Autriche

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Le document en format XML

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<term>Cell types</term>
<term>Cellular uptake</term>
<term>Charge ratio</term>
<term>Chem</term>
<term>Chloroquine</term>
<term>Circular dichroism</term>
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<term>Curiel</term>
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<term>Soluble complexes</term>
<term>Successful gene transfer</term>
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<term>Transfection</term>
<term>Transfection levels</term>
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<front><div type="abstract" xml:lang="en">Abstract: Receptor-mediated gene transfer is a promising gene delivery technique. It employs a DNA-binding polycation, such as polylysine, to compact plasmid DNA to a size that can be taken up by cells (<100–200 nm). To allow internalization by receptor-mediated endocytosis, cell binding ligands, such as asialoglycoproteins or galactose for hepatocytes, anti-CD3 and anti-CD5 for T-cells, and transferrin, have been covalently attached to polylysine. Intracellular barriers for successful gene transfer include release of DNA complexes from endosomes or lysosomes, nuclear import of DNA complexes, and disassembly of the DNA–polylysine particles. Release of particles from internal vesicles has been achieved by the addition of lysosomotropic agents or glycerol to the transfection medium, or by the incorporation of endosomolytic compounds, such as viruses or membrane active peptides. This technique has already been used to transfect certain organs in vivo, including liver and lung.</div>
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Polylysine-based transfection systems utilizing receptor-mediated delivery

Polylysine-based transfection systems utilizing receptor-mediated delivery

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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